Docendi.org

Arnold Schwarzenegger has nothing else to criticise Obama except his skinny legs�

Schlitzy — Thu, 05 Nov 2009 16:57:15 GMT

Now look at Arnold himself :
http://img101.imageshack.us/img101/5276/arniepsjq4.jpg

and his support of McBUSH!! Rightards should stop going to church,
because you can't wordship the devil and God at the same time, it is
written in the bible.

Jesus's claim: if you support evil-doers, you are evil-doer yourself.

Example:

Invading IRAQ killing million innocents there, you are part of it. They
didn't invade America bastard. No you didn't fight for our freedom, you
decreased our freedom, now it's harder and unsafer to move around, the
world hate us.

FREE ELECTRICITY!

Mr Green — Sat, 18 Jul 2009 02:17:08 GMT

Most residential electric users like YOU can receive anywhere from $25 to
$200 a month in free electricity just by completing a simple application for
it over the phone, or even online in some cases! Since eligibility has
nothing to do with income levels most applicants are normally approved
quickly and easily. YOU can be receiving FREE ELECTRICITY within 30 days!
http://xrl.us/freepower

FREE ELECTRICITY!

Mr Green — Sat, 18 Jul 2009 02:16:54 GMT

FREE ELECTRICITY!

Mr Green — Sat, 18 Jul 2009 02:16:27 GMT

FREE ELECTRICITY!

Mr Green — Sat, 18 Jul 2009 02:15:58 GMT

FREE ELECTRICITY!

Mr Green — Sat, 18 Jul 2009 02:15:35 GMT

Mr Green wrote:

> Most residential electric users like YOU can receive anywhere from $25 to
> $200 a month in free electricity just by completing a simple application for
> it over the phone, or even online in some cases! Since eligibility has
> nothing to do with income levels most applicants are normally approved
> quickly and easily. YOU can be receiving FREE ELECTRICITY within 30 days!
> http://xrl.us/freepower
>
>
TINSTAAFL

Continuous elimination of oxidized nucleotides is necessary toprevent rapid onset of cellular senescence.

rs1000b@yahoo.com — Tue, 06 Jan 2009 20:56:26 GMT

Proc Natl Acad Sci U S A. 2008 Dec 31. [Epub ahead of print]

Continuous elimination of oxidized nucleotides is necessary to prevent
rapid onset of cellular senescence.

Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA.

Whitehead Institute for Biomedical Research and.

Reactive oxygen species (ROS) appear to play a role in limiting both
cellular and organismic lifespan. However, because of their
pleiotropic effects, it has been difficult to ascribe a specific role
to ROS in initiating the process of cellular senescence. We have
studied the effects of oxidative DNA damage on cell proliferation,
believing that such damage is of central importance to triggering
senescence. To do so, we devised a strategy to decouple levels of 8-
oxoguanine, a major oxidative DNA lesion, from ROS levels. Suppression
of MTH1 expression, which hydrolyzes 8-oxo-dGTP, was accompanied by
increased total cellular 8-oxoguanine levels and caused early-passage
primary and telomerase-immortalized human skin fibroblasts to rapidly
undergo senescence, doing so without altering cellular ROS levels.
This senescent phenotype recapitulated several salient features of
replicative senescence, notably the presence of senescence-associated
beta-galactosidase (SA beta-gal) activity, apparently irreparable
genomic DNA breaks, and elevation of p21(Cip1), p53, and p16(INK4A)
tumor suppressor protein levels. Culturing cells under low oxygen
tension (3%) largely prevented the shMTH1-dependent senescent
phenotype. These results indicate that the nucleotide pool is a
critical target of intracellular ROS and that oxidized nucleotides,
unless continuously eliminated, can rapidly induce cell senescence
through signaling pathways very similar to those activated during
replicative senescence.

PMID: 19118192 [PubMed - as supplied by publisher]

X-47B - Wraps Come Off U.S. Navy's First Tailless, Stealthy UnmannedAircraft

Mike — Tue, 06 Jan 2009 20:54:18 GMT

video at http://www.navytimes.com/ under multimedia

Aviation week and space technology

Wraps Come Off U.S. Navy's First Tailless, Stealthy Unmanned Aircraft

Northrop Grumman's X-47B unmanned combat air system (UCAS)
demonstrator reveals an unprecedented emphasis on all-aspect stealth
for the maritime environment.

Unveiled at the company's Palmdale, Calif., site on Dec. 16, the X-47B
is the U.S. Navy's first dedicated stealth aircraft since the ill-
fated General Dynamics/McDonnell Douglas A-12, canceled in 1991. The
X-47B is designed to demonstrate technology for a naval UCAS that
would perform the stealthy strike mission originally intended for the
A-12, but with the much-increased range and endurance of an unmanned
aircraft.

The program's focus on low observability (LO) at sea potentially puts
the Navy on a fast track to catch up with the U.S. Air Force in
stealth design. But to be a viable option for the Navy's emerging F/A-
XX requirement for a 2025-timeframe strike aircraft, the UCAS must
show that it can replace a manned aircraft on carrier flight decks.

"She is as stealthy as she looks," says Scott Winship, Northrop
Grumman's Naval UCAS program manager. The tailless flying wing
combines "all-spectrum, all-aspect" low observability with the
ruggedness required for day-to-day shipboard operations, he adds.
Incorporating the B-2A bomber's low radar cross-section (RCS) design
aspects with the systems and control features of the much smaller
X-47A Pegasus demonstrator, the X-47B makes use of a wing-fold system
derived from the A-12.

The first air vehicle, AV-1, is scheduled to fly on Nov. 11, 2009,
while AV-2 will be completed around December 2009. Both will be used
to evaluate the viability of an unmanned combat aircraft in carrier
operations; the first X-47B carrier landing is expected in November
2011.

The outer 16 ft. of each wing folds up 135 deg. to reduce the overall
62.1-ft. wingspan to 30.9 ft. Achieving this with a wing-fold
mechanism that did not compromise the RCS with a "bulge" in the outer
mold line of the wing "was one of the more difficult design problems,"
says Winship. The same requirement drove the A-12 designers to develop
a "double roll" hinging mechanism that was modified by Northrop
Grumman to keep the X-47B wing skin smooth on both sides. The A-12
never advanced beyond the mockup stage.

The wing hinge line and narrowly slotted fold zone, although visible
on AV-1, are expected to be given LO treatment with blade seals
similar to those developed to cover the gaps between the edges of the
elevons and ailerons as well as the wing trailing-edge "island"
supporting structure. These were not shown at the rollout because of
their proprietary design. The edges of the island will also be inlaid
with conventional radar-defeating diamond, or cat's-eyes, shapes, says
Winship. GKN Aerospace developed the X-47B's composite skins, covers
and doors, and was responsible for the design, tooling and manufacture
of the outboard wing and the forward center fuselage section.

GKN also developed large blade seals to minimize potential radar
returns from the trailing-edge recess cavity exposed during aileron
movement. Described simply by Winship as a "new material," the radar-
absorbing material used in the broad seal is flexible and spring-
mounted to maintain tension over the forward section of the aileron.
The seal therefore moves with the aileron, but snaps shut to become
flush with the wing surface with the ailerons in a neutral position.
Roll and yaw control is also executed with very large spoiler panels
measuring 3 X 5 ft. on the upper wing surface forward of the ailerons.

Elevons can be drooped by 20 deg. for landing, but no deflection is
required for the catapult launch, says Winship. "We generate lift in a
hurry, so much so that we can launch off in any direction," he adds.
The company believes that being able to launch from the deck,
regardless of wind direction, significantly increases operational
flexibility as the carrier does not need to alter course into the
wind. "I don't know of any other aircraft that can do that," he says.

Lockheed Martin was responsible for refining the detailed low-
observable features of the leading and trailing edges, control
surfaces and engine inlet. The work was largely perfected on a full-
scale RCS pole model at Lockheed Martin's Helendale measurement
facility in the Mojave desert, about 25 mi. from Palmdale.

The shift to the larger, winged configuration of the X-47B away from
the sharp, diamond-kite-shaped X-47A - with a 55-deg. backward sweep
on the leading edge and a 35-deg. forward sweep on the trailing edge -
did not force Northrop Grumman "to give up on stealth," says Winship,
who describes the larger UCAS as a "six-pointer instead of a four-
pointer." The X-47B's wing extensions provide greater range and
superior flying qualities compared with the unstable X-47A, which
Winship called a "Flying Dorito" after the shape of a popular brand of
tortilla chip. The A-12 was also given the same nickname.

Structural proof tests will be conducted in a loads test rig scheduled
to run from March to May 2009. The tests will simulate carrier landing
and critical flight loads, as well as check the structure for catapult
and arrestment loads, fuel system integrity and control-surface
freedom under load. From June 2009 onward, engine run-ups and taxi
tests should take place prior to the vehicle's transfer to nearby
Edwards AFB for flight tests. The X-47B may fly the short distance or
"be trucked," he adds.

Following first flight, AV-1 will undergo a year-long envelope-
expansion test period at Edwards before being ferried to the naval
test center at NAS Patuxent River, Md. This phase will focus on
working up to carrier demonstrations, and will include catapult
certification tests at Lakehurst Naval Air Engineering Station, N.J.
Further tests will include a period at Norfolk, Va., where it will be
craned onto the deck of a Nimitz-class carrier for dock-side taxi
trials.

A final phase at Patuxent will be followed by a November 2011 landing
on a carrier at sea. This is likely to be the USS Truman, which "right
now looks as if it's going to be in the right place at the right
time," says Navy N-UCAS program manager Capt. Martin Deppe.

Flying saucers

gabydewilde — Tue, 06 Jan 2009 20:49:19 GMT

http://www.google.com/search?q=flyin...or+schauberger

http://www.google.com/search?q=flying+saucer+otis+carr

http://www.google.com/search?q=flyin...er+david+hamel

http://www.google.com/search?q=flying+saucer+john+searl

http://www.google.com/search?q=flyin...townsend+brown

Metabolism and Aging: Effects of Cold Exposure on Metabolic Rate,Body Composition, and Longevity in Mice.

rs1000b@yahoo.com — Tue, 06 Jan 2009 20:47:05 GMT

Physiol Biochem Zool. 2008 Dec 30. [Epub ahead of print]

Metabolism and Aging: Effects of Cold Exposure on Metabolic Rate, Body
Composition, and Longevity in Mice.

Vaanholt LM, Daan S, Schubert KA, Visser GH.

Department of Behavioural Biology, University of Groningen, P.O. Box
14, 9750 AA Haren, The Netherlands; 2Institute of Biological and
Environmental Sciences, University of Aberdeen, Tillydrone Avenue,
Aberdeen AB24 2TZ, Scotland; 3Centre for Isotope Research, Nijenborgh
4, 9747 AG Groningen, The Netherlands.

Abstract The proposition that increased energy expenditure shortens
life has a long history. The rate-of-living theory (Pearl 1928 )
states that life span and average mass-specific metabolic rate are
inversely proportional. Originally based on interspecific allometric
comparisons between species of mammals, the theory was later rejected
on the basis of comparisons between taxa (e.g., birds have higher
metabolic rates than mammals of the same size and yet live longer). It
has rarely been experimentally tested within species. Here, we
investigated the effects of increased energy expenditure, induced by
cold exposure, on longevity in mice. Longevity was measured in groups
of 60 male mice maintained at either 22 degrees C (WW) or 10 degrees C
(CC) throughout adult life. Forty additional mice were maintained at
both of these temperatures to determine metabolic rate (by stable
isotope turnover, gas exchange, and food intake) as well as the mass
of body and organs of subsets of animals at four different ages.
Because energy expenditure might affect longevity by either
accumulating damage or by instantaneously affecting mortality rate, we
included a third group of mice exposed to 10 degrees C early in life
and to 22 degrees C afterward (CW). Exposure to cold increased mean
daily energy expenditure by ca. 48% (from 47.8 kJ d(-1) in WW to 70.6
kJ d(-1) in CC mice, with CW intermediate at 59.9 kJ d(-1)). However,
we observed no significant differences in median life span among the
groups (WW, 832 d; CC, 834 d; CW, 751 d). CC mice had reduced body
mass (lifetime mean 30.7 g) compared with WW mice (33.8 g), and hence
their lifetime energy potential (LEP) per gram whole-body mass had an
even larger excess than per individual. Greenberg ( 1999 ) has pointed
out that the size of the energetically costly organs, rather than that
of the whole body, may be relevant for the rate-of-living idea. We
therefore expressed LEP also in terms of energy expenditure per gram
dry lean mass or per gram "metabolic" organ mass (i.e., heart, liver,
kidneys, and brain). No matter how it was expressed, LEP in CC mice
significantly exceeded that of WW mice. This result demonstrates that
increased energy expenditure does not shorten life span and adds
evidence to the intraspecific refutation of the rate-of-living theory.
We suggest that increased energy expenditure has both positive and
negative effects on different factors determining life span and that
the relationship between energy turnover and longevity is
fundamentally nonmonotonic.

PMID: 19115965 [PubMed - as supplied by publisher]

transmutation of elements

gabydewilde — Tue, 06 Jan 2009 20:44:44 GMT

http://www.google.com/search?q=trans...Walter+russell

High-dose B vitamin supplementation significantly reduces progressionof early-stage subclinical atherosclerosis.

rs1000b@yahoo.com — Tue, 06 Jan 2009 20:41:45 GMT

Stroke. 2008 Dec 31. [Epub ahead of print]

High-Dose B Vitamin Supplementation and Progression of Subclinical
Atherosclerosis. A Randomized Controlled Trial.

Hodis HN, Mack WJ, Dustin L, Mahrer PR, Azen SP, Detrano R, Selhub J,
Alaupovic P, Liu CR, Liu CH, Hwang J, Wilcox AG, Selzer RH; for the
BVAIT Research Group.

From the Atherosclerosis Research Unit, the Department of Preventive
Medicine, the Department of Medicine, and the Department of Radiology,
University of Southern California, Keck School of Medicine, Los
Angeles, Calif; the Department of Molecular Pharmacology and
Toxicology, University of Southern California, School of Pharmacy, Los
Angeles, Calif; Kaiser Permanente Medical Center, Los Angeles, Calif;
Harbor-University of California at Los Angeles Medical Center, Los
Angeles, Calif; the USDA Human Nutrition Research Center on Aging and
Department of Vitamin Metabolism and Aging, Tufts University, Boston,
Mass; Oklahoma Medical Research Foundation, Oklahoma City, Okla; and
the Jet Propulsion Laboratory, California Institute of Technology,
Pasadena, Calif.

BACKGROUND AND PURPOSE: Although plasma total homocysteine (tHcy)
levels are associated with cardiovascular disease, it remains unclear
whether homocysteine is a cause or a marker of atherosclerotic
vascular disease. We determined whether reduction of tHcy levels with
B vitamin supplementation reduces subclinical atherosclerosis
progression. METHODS: In this double-blind clinical trial, 506
participants 40 to 89 years of age with an initial tHcy >8.5 micromol/
L without diabetes and cardiovascular disease were randomized to high-
dose B vitamin supplementation (5 mg folic acid+0.4 mg vitamin B12+50
mg vitamin B6) or matching placebo for 3.1 years. Subclinical
atherosclerosis progression across 3 vascular beds was assessed using
high-resolution B-mode ultrasonography to measure carotid artery
intima media thickness (primary outcome) and multidetector spiral CT
to measure aortic and coronary artery calcium (secondary outcome).
RESULTS: Although the overall carotid artery intima media thickness
progression rate was lower with B vitamin supplementation than with
placebo, statistically significant between-group differences were not
found (P=0.31). However, among subjects with baseline tHcy >/=9.1
micromol/L, those randomized to B vitamin supplementation had a
statistically significant lower average rate of carotid artery intima
media thickness progression compared with placebo (P=0.02); among
subjects with a baseline tHcy <9.1 micromol/L, there was no
significant treatment effect (probability value for treatment
interaction=0.02). B vitamin supplementation had no effect on
progression of aortic or coronary artery calcification overall or
within subgroups. CONCLUSIONS: High-dose B vitamin supplementation
significantly reduces progression of early-stage subclinical
atherosclerosis (carotid artery intima media thickness) in well-
nourished healthy B vitamin "replete" individuals at low risk for
cardiovascular disease with a fasting tHcy >/=9.1 micromol/L.

PMID: 19118243 [PubMed - as supplied by publisher]

A New Indicator for Climate Change?

David — Tue, 06 Jan 2009 20:36:06 GMT

On Jan 6, 2:36*pm, David wrote:
> Accuweatherhttp://global-warming.accuweather.com/2009/01/a_new_indicator_for_cli...
>
> David Christainsen - Meteorologist

Too bad 1938 was one of the warmest years in the recorded history.
Just ask Fudger Hansen 'bout it.

A New Indicator for Climate Change?

David — Tue, 06 Jan 2009 20:36:06 GMT

Synthesis and In-vitro Studies of SkQ Mitochondrial Antioxidants

rs1000b@yahoo.com — Tue, 06 Jan 2009 20:34:04 GMT

Biochemistry (Mosc). 2008 Dec;73(12):1273-87.

Mitochondria-Targeted Plastoquinone Derivatives as Tools to Interrupt
Execution of the Aging Program. 1. Cationic Plastoquinone Derivatives:
Synthesis and in vitro Studies.

Antonenko YN, Avetisyan AV, Bakeeva LE, Chernyak BV, Chertkov VA,
Domnina LV, Ivanova OY, Izyumov DS, Khailova LS, Klishin SS,
Korshunova GA, Lyamzaev KG, Muntyan MS, Nepryakhina OK, Pashkovskaya
AA, Pletjushkina OY, Pustovidko AV, Roginsky VA, Rokitskaya TI, Ruuge
EK, Saprunova VB, Severina II, Simonyan RA, Skulachev IV, Skulachev
MV, Sumbatyan NV, Sviryaeva IV, Tashlitsky VN, Vassiliev JM, Vyssokikh
MY, Yaguzhinsky LS, Zamyatnin AA Jr, Skulachev VP.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow
State University, Moscow, 119991, Russia. skulach***belozersky.msu.ru.

Synthesis of cationic plastoquinone derivatives (SkQs) containing
positively charged phosphonium or rhodamine moieties connected to
plastoquinone by decane or pentane linkers is described. It is shown
that SkQs (i) easily penetrate through planar, mitochondrial, and
outer cell membranes, (ii) at low (nanomolar) concentrations, posses
strong antioxidant activity in aqueous solution, BLM, lipid micelles,
liposomes, isolated mitochondria, and cells, (iii) at higher
(micromolar) concentrations, show pronounced prooxidant activity, the
"window" between anti- and prooxidant concentrations being very much
larger than for MitoQ, a cationic ubiquinone derivative showing very
much lower antioxidant activity and higher prooxidant activity, (iv)
are reduced by the respiratory chain to SkQH2, the rate of oxidation
of SkQH2 being lower than the rate of SkQ reduction, and (v) prevent
oxidation of mitochondrial cardiolipin by OH*. In HeLa cells and human
fibroblasts, SkQs operate as powerful inhibitors of the ROS-induced
apoptosis and necrosis. For the two most active SkQs, namely SkQ1 and
SkQR1, C(1/2) values for inhibition of the H2O2-induced apoptosis in
fibroblasts appear to be as low as 1x10(-11) and 8x10(-13) M,
respectively. SkQR1, a fluorescent representative of the SkQ family,
specifically stains a single type of organelles in the living cell,
i.e. energized mitochondria. Such specificity is explained by the fact
that it is the mitochondrial matrix that is the only negatively-
charged compartment inside the cell. Assuming that the Deltapsi values
on the outer cell and inner mitochondrial membranes are about 60 and
180 mV, respectively, and taking into account distribution coefficient
of SkQ1 between lipid and water (about 13,000 : 1), the SkQ1
concentration in the inner leaflet of the inner mitochondrial membrane
should be 1.3x10(8) times higher than in the extracellular space. This
explains the very high efficiency of such compounds in experiments on
cell cultures. It is concluded that SkQs are rechargeable,
mitochondria-targeted antioxidants of very high efficiency and
specificity. Therefore, they might be used to effectively prevent ROS-
induced oxidation of lipids and proteins in the inner mitochondrial
membrane in vivo.

PMID: 19120014 [PubMed - in process]